Mots C - 10mg

What's Included

MOTS-10 | 10mg MOTS-C vial – bacteriostatic water required (sold separately)

The Mitochondrial Peptide for Metabolic Health and Longevity Research

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide that regulates metabolic homeostasis and cellular energy production. Discovered in 2015, MOTS-c acts as a retrograde signaling molecule, communicating from mitochondria to the nucleus to optimize metabolism and stress resistance.

RESEARCH HIGHLIGHTS

Enhanced Metabolic Function

Improves glucose metabolism and insulin sensitivity in preclinical studies. Research shows significant effects on metabolic regulation, making it a focus in diabetes and obesity research models.

Increased Energy Production

Optimizes mitochondrial function and ATP production. Studies demonstrate improved cellular energy efficiency and metabolic flexibility across tissue types.

Exercise Mimetic Effects

Activates AMPK (AMP-activated protein kinase) pathways, mimicking benefits of physical exercise. Research shows enhanced endurance, improved muscle function, and metabolic adaptation.

Longevity and Age-Related Protection

Demonstrates protective effects against age-related metabolic decline. Studies indicate improved healthspan markers and resistance to metabolic dysfunction associated with aging.

Stress Resistance

Enhances cellular adaptation to metabolic and oxidative stress. Research shows improved cellular resilience and metabolic regulation under challenging conditions.

MECHANISM OF ACTION

MOTS-c translocates to the cell nucleus under metabolic stress, regulating nuclear gene expression and activating adaptive pathways. It primarily works through AMPK activation, improving glucose uptake, fatty acid oxidation, and mitochondrial biogenesis — key processes in metabolic health and longevity.

KEY RESEARCH APPLICATIONS

Metabolic Health: Glucose regulation, insulin sensitivity, obesity research, diabetes models

Exercise Physiology: Endurance enhancement, muscle function, metabolic adaptation, performance studies

Aging Research: Healthspan extension, age-related metabolic decline, longevity pathways

Cellular Energy: Mitochondrial function, ATP production, metabolic flexibility, energy optimization

CLINICAL INTEREST

MOTS-c represents a novel class of mitochondrial-derived peptides with potential applications in metabolic disease, aging research, and performance optimization studies. Its unique retrograde signaling mechanism offers insights into mitochondrial-nuclear communication.

FOR RESEARCH USE ONLY

MOTS-c is supplied for laboratory and research purposes only. Not intended for human consumption or therapeutic use.